Karen M. Rodrigue, Ph. D.
Assistant Professor of Behavioral and Brain Sciences

Center for Vital Longevity
1600 Viceroy Drive,
Suite 800


Cognitive Neuroscience of Aging Lab

“Understanding the contributions of vascular health to normal and pathological aging is fundamentally important given both the prevalence of vascular risk in the aging population and its amenability to prevention and treatment.”

Research interests:

Keywords: cognitive aging, structural and functional changes with age, amyloid imaging, impact of health on brain aging, genetic influences on aging, individual differences

Dr. Rodrigue's research focuses on mapping the changes that the healthy human brain undergoes with aging and understanding how these changes affect behavior. She is specifically interested in how health factors such as hypertension in combination with genetic risk can shape the course of aging. Our lab uses a variety of tools to assess brain and cognitive aging including structural and functional MRI, beta-amyloid PET imaging and detailed cognitive and neuropsychological assessment.

Recent Publications

Foster, C. M., Kennedy, K. M., Hoagey, D. A., Horn, M. M., Rodrigue, K. M. (2018). Both hyper- and hypo-activation to cognitive challenge are associated with increased beta-amyloid deposition in healthy aging: A nonlinear effect. NeuroImage, 166, 285-292. (DOI:10.1016/j.neuroimage.2017.10.068 )

Horn, M. M., Kennedy, K. M., & Rodrigue, K. M. (in press). Association between subjective memory assessment and associative memory performance: Role of AD risk factors. Psychology and Aging, Special Issue on Age-Related Differences in Associative Memory: Empirical Evidence and Theoretical Perspectives.

Kennedy, K. M., Boylan, M. A., Rieck, J. R., Foster, C. M., & Rodrigue, K. M. (2017). Dynamic range in BOLD modulation: Lifespan aging trajectories and association with performance. Neurobiology of Aging, 60, 153-163. (DOI: 10.1016/j.neurobiolaging.2017.08.027)

Rieck, J. R., Rodrigue, K. M., Boylan, M. A., Kennedy, K. M. (2017). Age-related Reduction of BOLD Modulation to Cognitive Difficulty Predicts Poorer Task Accuracy and Poorer Fluid Reasoning Ability. NeuroImage, 147, 262-271. (DOI: 10.1016/j.neuroimage.2016.12.022)

Kennedy, K. M., Rieck, J. R., Boylan, M. A., Rodrigue, K. M. (2017). Functional magnetic resonance imaging data of incremental increases in visuo-spatial difficulty in a large adult lifespan sample. Data in Brief, 11, 54-60. (DOI: 10.1016/j.dib.2017.01.004)

Rodrigue, K. M. & Bischof, G. (2017). The modifying role of hypertension in cognitive and brain aging. In R. Cabeza, L. Nyberg, & D.C. Park (Eds.), Cognitive Neuroscience of Aging,2nd Edition, (389-414). New York,NY: Oxford University Press. (DOI: 10.1093/acprof:oso/9780199372935.003.0016)