Kennedy Neuroimaging of Aging and Cognition Lab

2017

Gerstenecker, A., Hoagey, D.A., Marson, D. C., Kennedy, K.M. (in press). White Matter Degradation is Associated with Reduced Financial Capacity in Mild Cognitive Impairment and Alzheimer’s Disease. Journal of Alzheimer’s Disease.

Foster, C. M., Kennedy, K. M., & Rodrigue, K. M. (2017). Differential aging trajectories of modulation of activation to cognitive challenge in APOE ε4 groups: Reduced modulation predicts poorer cognitive performance. Journal of Neuroscience37(29), 6894-6901.

Farrell, M.E., Kennedy, K.M., Rodrigue, K.M., Wig, G., Bischof, G.N., Rieck, J.R., Chen, X., Festini, S.B., Devous, M.D., Park, D.C. (2017) Association of longitudinal cognitive decline with amyloid burden in middle-aged and older adults: Evidence for a dose-response relationship. JAMA Neurology, 74(7), 830-838. doi: 10.1001/jamaneurol.2017.0892.

*Rast, P., *Kennedy, K. M., Rodrigue, K. M., Robinson, P.R.A.W., Gross, A.L., McClaren, D.G., Grabowski, T., Schaie, K.W., Willis, S. L. (2017). APOEε4 Genotype and Hypertension Modify 8-year Cortical Thinning: Five Occasion Evidence from the Seattle Longitudinal Study. Cerebral Cortex, in press. *Shared first authorship.

Rieck, J. R., Rodrigue, K. M., Boylan, M. A., Kennedy, K. M. (2017). Age-related Reduction of BOLD Modulation to Cognitive Difficulty Predicts Poorer Task Accuracy and Poorer Fluid Reasoning Ability. NeuroImage, 147, 262-271. http://dx.doi.org/10.1016/j.neuroimage.2016.12.022

Kennedy, K. M., Rieck, J. R., Boylan, M. A., Rodrigue, K. M. (2017). Functional magnetic resonance imaging data of incremental increases in visuo-spatial difficulty in a large adult lifespan sample. Data in Brief, 11, 54-60. http://dx.doi.org/10.1016/j.dib.2017.01.004

Wisse, L. E. M., Daugherty, A. M., Olsen, R. K., Berron, D., Carr, V. A., Stark, C. E. L., Amaral, R. S. C., Amunts, K., Augustinack, J. C., Bender, A. R., Bernstein, J. D., Boccardi, M., Bocchetta, M., Burggren, A., Chakravarty, M. M., Chupin, M., Ekstrom, A., de Flores, R., Insausti, R., Kanel, P., Kedo, O., Kennedy, K. M., Kerchner, G. A., LaRocque, K., Liu, X., Maass, A., Malykhin, N., Mueller, S. G., Ofen, N., Palombo, D. J., Parekh, M. B., Pluta, J. B., Pruessner, J. C., Raz, N., Rodrigue, K. M., Schoemaker, D., Shafer, A.T., Steve, T. A., Suthana, N., Wang, L., Winterburn, J. L., Yassa, M. A., Yushkevich, P. A., la Joie, R., for the Hippocampal Subfields Group (2017). A harmonized segmentation protocol for hippocampal and parahippocampal subregions: Why do we need one and what are the key goals? Hippocampus, 27(1), 3-11. doi: 10.1002/hipo.22671. PMID: 27862600.

Savalia, N. K., Agres, P. F., Chan, M. Y., Feczko, E. J., Park, D. C., Kennedy. K. M., Wig, G. S. (2017). Motion-related noise in structural brain images may be revealed with independent estimates of in-scanner head motion. Human Brain Mapping, 38(1), 472-492. doi: 10.1002/hbm.23397. PMID: 27634551

2016

Bischof, G. N., Rodrigue, K. M., Kennedy, K. M., Devous, M. D., Park, D. C. (2016). Amyloid deposition in younger adults is linked to episodic memory performance. Neurology, 87(24), 2562-2566. PMID: 27837001

McDonough, I. M., Bischof, G. N., Kennedy, K. M., Rodrigue, K. M., Farrell, M. E., Park, D. C. (2016). Discrepancies between Fluid and Crystallized Ability in Healthy Adults: A Behavioral Marker of Preclinical Alzheimer’s Disease. Neurobiology of Aging, 46, 68-75. PMID: PMC5018443

2015

Kennedy, K. M., & Raz, N. (2015). Normal Aging of the Brain. In: A. W. Toga (Ed), Brain Mapping: An Encyclopedic Reference, vol 3, ch 68, pp 603-617. Academic Press: Elsevier.

Rieck, J. R., Rodrigue, K. M., Kennedy, K. M., Devous, M. D., & Park, D. C. (2015). The effect of beta‐amyloid on face processing in young and old adults: A multivariate analysis of the BOLD signal. Human Brain Mapping, 36(7), 2514-2526. http://dx.doi.org/10.1002/hbm.22788

Kennedy, K. M., Rodrigue, K. M., Bischof, G. N., Hebrank, A. C., Reuter-Lorenz, P. A., & Park, D. C. (2015). Age trajectories of functional activation under conditions of low and high processing demands: an adult lifespan fMRI study of the aging brain. NeuroImage, 104, 21-34. http://dx.doi.org/10.1016/j.neuroimage.2014.09.056

Kennedy, K. M., Reese, E., Horn, M., Sizemore, A., Unni, A., Meerbrey, M., Kalich, A., Rodrigue, K. M. (2015). BDNF val66met Polymorphism Affects Aging of Multiple Types of Memory. Brain Research, 1612(0), 104-117. http://dx.doi.org/10.1016/j.brainres.2014.09.044 Download PDF

2014

King, R. D., Kole, S. Kennedy, K. M., Rodrigue, K. M., Brown, B., Berberich, J., Park, D. C. (under revision). Fractal Analysis of the Cerebral Cortical Ribbon Across the Adult Lifespan.

Bischof, G. N., Kennedy, K. M., Devous, M. D., Rodrigue, K. M., Rieck, J. R., Park, D. C. (submitted). Does Beta-Amyloid Deposition Interact with White Matter Hyperintensities to Predict Cognitive Function?

2013

Liu, P., Hebrank, A. C., Rodrigue, K. M., Kennedy, K. M., Section, J., Park, D. C., Lu, H. (2013). Age-related differences in memory-encoding fMRI responses after accounting for decline in vascular reactivity.  NeuroImage, 78, 415-425. (PMID: 23624491)

Liu, P., Hebrank, A. C., Rodrigue, K. M., Kennedy, K. M., Park. D. C., & Lu, H. (2013). A comparison of physiologic modulators of fMRI signals. Human Brain Mapping, 34(9), 2078-2088. (PMID: 224612341)

Raz, N., Schmiedek, F., Rodrigue, K. M., Kennedy, K. M., Lindenberger, U., & Lövdén, M. (2013). Differential Brain Shrinkage Over Six Months Shows  Limited Association with Cognitive Practice. Brain and Cognition, 82, 171-180. (PMID: 23665948)

Park, H., Kennedy, K. M., Rodrigue, K. M., Hebrank, A. C., & Park, D. C. (2013). An fMRI study of episodic encoding across the lifespan: Changes in subsequent memory effects are evident by middle-age. Neuropsychologia, 51, 448-456. (PMID: 23219676)

Rodrigue, K. M., Rieck, J. R., Kennedy, K. M., Devous, M. D., Diaz-Arrastia, R., Park, D. C. (2013). Risk Factors for Amyloid Deposition in Healthy Aging: Interactive Effects of Vascular and Genetic Risk. JAMA Neurology, 70(5), 600-6. (PMID: 23553344)

2012

Lövdén, M., Schmiedek, F., Kennedy, K. M., Rodrigue, K.M., Raz, N., & Lindenberger, U. (2012). Does Variability in Cognitive Performance Correlate with Frontal Brain Volume? NeuroImage, 64(1), 209-215. (PMID: 23000256)

Kennedy, K. M., Rodrigue, K.M., Devous, M. D., Sr., Hebrank, A. C., Bischof, G. N.,  & Park, D. C. (2012). Beta-Amyloid Burden is Associated with Altered Functional Activation During Encoding Across the Adult Lifespan. NeuroImage, 62 (1), 1-8.

Park, J., Carp, J., Kennedy, K. M., Rodrigue, K. M., Bischof, G. N., Huang, C. M., Rieck, J. R., Polk, T., & Park, D. C. (2012). Neural broadening or neural attenuation?  Age-related dedifferentiation in the face network in a large lifespan sample. Journal of Neuroscience, 32, 2154-2158. (PMID: 22323727)

Rodrigue, K. M., Kennedy, K. M., Devous, M. D., Sr., Rieck, J. R., Hebrank, A. C., Diaz-Arrastia, R., Mathews, D., & Park, D. C. (2012). β-Amyloid Burden in Healthy Aging: Regional Distribution and Cognitive Consequences. Neurology, 78, 387-395. (PMID: 22302550)

Raz, N., Yang, Y., Rodrigue, K. M., Kennedy, K. M., Lindenberger, U., & Ghisletta, P. (2012). White Matter Deterioration in 15 months: Latent Growth Curve Models in Healthy Adults. Neurobiology of Aging, 33(2), 429.e1–429.e5. (PMID: 21194799)

2011

Rodrigue, K. M. & Kennedy, K. M. (2011). The cognitive consequences of structural changes to the aging brain. In K. W. Schaie, S. L. Willis (Eds.) Handbook of the Psychology of Aging, 7th ed., Ch 5, 73-92, New York:Elsevier.

Shing, Y. L., Rodrigue, K. M., Kennedy, K. M., Fandakova, Y., Bodammer, N., Werkle-Bergner, M., Lindenberger, U., Raz, N. (2011). Hippocampal subfield volumes: Age, vascular risk, and correlation with associative memory. Frontiers in Aging Neuroscience, Feb 4;3:2. (PMID: 21331174

Lu, H., Xu, F., Rodrigue, K. M., Kennedy, K. M., Cheng, Y., Flicker, B., Hebrank, A. C., Uh, J., & Park, D. C. (2011). Alterations in cerebral metabolic rate and vascular function across the adult lifespan. Cerebral Cortex, 21, 1426-1434. (PMID: 21051551)

Raz, N., Dahle, C. L., Rodrigue, K. M., Kennedy, K. M., & Land, S. (2011).  Effects of age, genes, and pulse pressure on executive functions in healthy adults. Neurobiology of Aging, 32, 1124–1137. (PMID: 19559505)

2010

Raz, N., Ghisletta, P., Rodrigue, K. M. Kennedy, K. M., & Lindenberger, U. (2010). Trajectories of brain aging in middle-aged and older adults: Regional and individual differences. NeuroImage, 51, 501–511. PMC2879584

Ghisletta, P., Kennedy, K. M., Rodrigue, K.M., Lindenberger, U., & Raz, N. (2010). Adult age differences and the role of cognitive resources in perceptual-motor skill acquisition: Application of a multilevel negative exponential model. Journals of Gerontology: Psychological Sciences, 65B, (2), 163-173. PMC2981445

2009

Rodrigue, K. M., Kennedy, K.M., & Park, D. C. (2009). Beta-amyloid deposition and the aging brain. Neuropsychology Review, 19, 436-450. PMC2844114

Kennedy, K.M., & Raz, N. (2009). Pattern of normal age-related regional differences in white matter microstructure is modified by vascular risk. Brain Research, 1297, 41-56. PMC2758325

Kennedy, K. M., Rodrigue, K. M., Land, S., & Raz, N. (2009). BDNF val66met polymorphism influences age differences in microstructure of the corpus callosum. Frontiers in Human Neuroscience, 3:19. doi:10.3389/neuro.09.019.2009. PMC2737488

Kennedy, K.M., & Raz, N. (2009). Aging white matter and cognition: Differential effects of regional variations in diffusion properties on memory, executive functions, and speed. Neuropsychologia, 47(3), 916-927. PMC2643310

Kennedy, K.M., Rodrigue, K.M., Head, D., Gunning-Dixon, F., & Raz, N. (2009). Neuroanatomical and cognitive mediators of age-related differences in perceptual priming and learning. Neuropsychology, 23, (4), 475–491. PMC2754698

Head, D., Kennedy, K. M., Rodrigue, K. M., & Raz, N. (2009). Age-Differences in Perseveration: Cognitive and neuroanatomical mediators of performance on the Wisconsin Card Sorting Test. Neuropsychologia, 47(4), 1200-1203. PMC2649973   

Deshmukh, A. B., Rodrigue, K. M., Kennedy, K. M., Land, S., Jacobs, B. S., & Raz, N. (2009). Synergistic effects of the MTHFR C677T polymorphism and hypertension on spatial navigation. Biological Psychology, 80, 240-245. PMC2685204   

Raz, N., Rodrigue, K. M., Kennedy, K. M., & Land, S. (2009). Genetic and vascular modifiers of age-sensitive cognitive skills: Effects of COMT, BDNF, ApoE and hypertension. Neuropsychology, 23(1), 105-116.PMC2729285

Kennedy, K. M., Erickson, K. I., Rodrigue, K. M., Voss, M. W., Colcombe, S. J., Kramer, A. F., Acker, J. D., & Raz, N. (2009). Age-related differences in regional brain volumes: A comparison of optimized voxel-based morphometry to manual volumetry. Neurobiology of Aging, 30(10), 1657-1676. PMC2756236

Kennedy, K. M., Hope, K., & Raz, N. (2009). Lifespan adult faces: Norms for age, familiarity, memorability, mood, and picture quality. Experimental Aging Research, 35(2), 268-275. PMC2745897

Raz, N., & Kennedy, K.M. (2009). A systems approach to age-related change: Neuroanatomical changes, their modifiers, and cognitive correlates. In: W. Jagust, & M. D’Esposito (Eds.) Imaging the Aging Brain. Ch 4, pp. 43-70. New York, NY: Oxford University Press.

2008

Raz, N., Dahle, C. L., Rodrigue, K. M., Kennedy, K. M., Land, S., & Jacobs, B. S. (2008). Brain-Derived Neurotrophic Factor Val66Met and blood glucose: A synergistic effect on memory. Frontiers in Human Neuroscience, 2:12. doi:10.3389/neuro.09.012.2008. PMC2572208

Head, D., Rodrigue, K. M., Kennedy, K.M., & Raz, N. (2008). Neuroanatomical and cognitive mediators of age-related differences in episodic memory. Neuropsychology, 22(4), 491-507. PMC2688704

Raz, N., Lindenberger, U., Ghisletta, P., Rodrigue, K. M., Kennedy, K. M., & Acker, J. D. (2008). Neuroanatomical correlates of fluid intelligence in healthy adults and persons with vascular risk factors. Cerebral Cortex 18, 718-726. PMC2657233

Kennedy, K.M., Partridge, T., & Raz, N. (2008). Age-related differences in acquisition of perceptual-motor skills: working memory as a mediator. Aging, Neuropsychology and Cognition, 15(2), 165-183. 

2007

Raz, N., Rodrigue, K. M., Kennedy, K. M., & Acker, J. D. (2007). Vascular health and longitudinal changes in brain and cognition in middle-aged and older adults. Neuropsychology, 21(2), 149-157.

Kennedy, K. M., Rodrigue, K. M., & Raz, N. (2007). Fragmented pictures revisited: Long-term changes in repetition priming, relation to skill learning, and the role of cognitive resources. Gerontology, 53(3), 148-158.

Moffat, S. D., Kennedy, K. M., Rodrigue, K. M., & Raz, N. (2007). Age-differences in human spatial navigation: Extra-hippocampal contributions. Cerebral Cortex, 17, 1274-1282.

2005

Rodrigue, K. M., Kennedy, K. M., & Raz, N. (2005). Aging and longitudinal change in perceptual-motor skill acquisition in healthy adults. Journal of Gerontology: Psychological Science, 60(4), P174-P181.

Raz, N., Lindenberger, U., Rodrigue, K. M., Kennedy, K. M., Head, D., Williamson, A., Dahle, C., Gerstorf, D. & Acker, J.D. (2005). Regional brain changes in aging healthy adults: General trends, individual differences, and modifiers. Cerebral Cortex, 15(11), 1676-1689.

 Kennedy, K. M., & Raz, N. (2005). Age, sex, and regional brain volumes predict perceptual-motor skill acquisition in healthy adults. Cortex, Special Issue: Cognition and the Ageing Brain, 41(4), 560-569.

2004

Raz, N., Rodrigue, K. M., Kennedy, K. M., & Acker, J. D. (2004). Hormone replacement therapy and age-related brain shrinkage: Regional effects. NeuroReport, 15(16), 2531-2534.

Raz, N., Rodrigue, K. M., Head, D., Kennedy, K. M., & Acker, J. D. (2004). Differential changes in the medial temporal structures: A five-year longitudinal study. Neurology, 62 (3) 433-438.

2003

Raz, N., Rodrigue, K. M., Kennedy, K. M., Head, D., Gunning-Dixon, F., Acker, J. D. (2003). Aging of the human striatum: Longitudinal evidence. American Journal of Neuroradiology, 24, 1849-1856. PMC14561615

Raz, N., Rodrigue, K. M., Kennedy, K. M., Head, D., Dahle, C., & Acker, J. D. (2003). Age-related changes in the regional metencephalic volumes in humans: A five-year follow-up. Neuroscience Letters, 349(3), 163-166.

2000 and earlier

Kennedy, K. M., Rodrigue, K. M., & Davis, S. F. (2000). So you want to teach less in hopes of teaching more? College Student Journal, 34(4), 626-632.              

Kennedy, K. M., Nowak, S., Sundaram, R., Thomas, J., & Davis, S. F. (2000). Academic dishonesty and distance learning: Student and faculty views. College Student Journal, 34(2), 309-314.

Kennedy, K. M. & Emerson, A. E. (1996). Embarrassment as a determination of prosocial behavior: The “clumsy shopper” model. Proceedings of the Tenth National Conference on Undergraduate Research, 1, 37-38.