Karen M. Rodrigue, Ph. D.
Assistant Professor of Behavioral and Brain Sciences

Center for Vital Longevity
1600 Viceroy Drive,
Suite 800

agingbrain@utdallas.edu
972-883-3742

Publications

2017

Foster, C. M., Kennedy, K. M., & Rodrigue, K. M. (2017). Differential aging trajectories of modulation of activation to cognitive challenge in APOE ε4 groups: Reduced modulation predicts poorer cognitive performance. Journal of Neuroscience37(29), 6894-6901.

Farrell, M.E., Kennedy, K.M., Rodrigue, K.M., Wig, G., Bischof, G.N., Rieck, J.R., Chen, X., Festini, S.B., Devous, M.D., Park, D.C. (2017) Association of longitudinal cognitive decline with amyloid burden in middle-aged and older adults: Evidence for a dose-response relationship. JAMA Neurology, 74(7), 830-838. doi: 10.1001/jamaneurol.2017.0892.

*Rast, P., *Kennedy, K. M., Rodrigue, K. M., Robinson, P.R.A.W., Gross, A.L., McClaren, D.G., Grabowski, T., Schaie, K.W., Willis, S. L. (2017). APOEε4 Genotype and Hypertension Modify 8-year Cortical Thinning: Five Occasion Evidence from the Seattle Longitudinal Study. Cerebral Cortex, in press. *Shared first authorship.

Rieck, J. R., Rodrigue, K. M., Boylan, M. A., Kennedy, K. M. (2017). Age-related Reduction of BOLD Modulation to Cognitive Difficulty Predicts Poorer Task Accuracy and Poorer Fluid Reasoning Ability. NeuroImage, 147, 262-271. http://dx.doi.org/10.1016/j.neuroimage.2016.12.022

Kennedy, K. M., Rieck, J. R., Boylan, M. A., Rodrigue, K. M. (2017). Functional magnetic resonance imaging data of incremental increases in visuo-spatial difficulty in a large adult lifespan sample. Data in Brief, 11, 54-60. http://dx.doi.org/10.1016/j.dib.2017.01.004

Rodrigue, K. M. & Bischof, G. (2017). The modifying role of hypertension in cognitive and brain aging. In R. Cabeza, L. Nyberg, & D.C. Park (Eds.), Cognitive Neuroscience of Aging,2nd Edition, (389-414). New York,NY: Oxford University Press.

2016

Wisse, L. E. M., Daugherty, A. M., Olsen, R. K., Berron, D., Carr, V. A., Stark, C. E. L., Amaral, R. S. C., Amunts, K., Augustinack, J. C., Bender, A. R., Bernstein, J. D., Boccardi, M., Bocchetta, M., Burggren, A., Chakravarty, M. M., Chupin, M., Ekstrom, A., de Flores, R., Insausti, R., Kanel, P., Kedo, O., Kennedy, K. M., Kerchner, G. A., LaRocque, K., Liu, X., Maass, A., Malykhin, N., Mueller, S. G., Ofen, N., Palombo, D. J., Parekh, M. B., Pluta, J. B., Pruessner, J. C., Raz, N., Rodrigue, K. M., Schoemaker, D., Shafer, A.T., Steve, T. A., Suthana, N., Wang, L., Winterburn, J. L., Yassa, M. A., Yushkevich, P. A., la Joie, R., for the Hippocampal Subfields Group (2016). A harmonized segmentation protocol for hippocampal and parahippocampal subregions: Why do we need one and what are the key goals? Hippocampus, 27(1), 3-11. doi: 10.1002/hipo.22671. PMID: 27862600.

McDonough, I. M., Bischof, G. N., Kennedy,K. M.,Rodrigue, K. M., Farrell, M. E., Park, D. C. (2016). Discrepancies between Fluid and Crystallized Ability in Healthy Adults: A Behavioral Marker of Preclinical Alzheimer’s Disease. Neurobiology of Aging, 46,69-75. PMID: PMC5018443

 


2015

Kennedy, K. M., Reese, E., Horn, M., Sizemore, A., Unni, A., Meerbrey, M., Kalich, A., Rodrigue, K. M. (2015). BDNF val66met Polymorphism Affects Aging of Multiple Types of Memory. Brain Research, Special Issue on Memory and Aging,1612, 104-117. PMC4377126

Kennedy, K. M., Rodrigue, K. M., Bischof, G. N., Hebrank, A. C., Reuter-Lorenz, P. A., Park, D. C. (2015). Age Trajectories of Functional Activation Under Conditions of Low and High Processing Demands: An Adult Lifespan fMRI Study of the Aging Brain. NeuroImage, 104, 21-34. PMC4252495

Rieck, J. R., Rodrigue, K. M., Kennedy, K. M., Devous, M. D., Sr., Park, D. C. (2015). The effect of beta-amyloid on face processing in young and old adults: A multivariate analysis of the BOLD signal. Human Brain Mapping, 36(7), 2514-2526. PMC4617762

 


2013

Rodrigue, K.M. (2013). Contribution of Cerebrovascular Health to the Diagnosis of Alzheimer Disease. JAMA Neurology, 70(4),438-439.

Liu, P., Hebrank, A. C., Rodrigue, K. M., Kennedy, K. M., Section, J., Park, D. C., Lu, H. (2013). Age-related differences in memory-encoding fMRI responses after accounting for decline in vascular reactivity.  NeuroImage, 78, 415-425.

Liu, P., Hebrank, A. C., Rodrigue, K. M., Kennedy, K. M., Park. D. C., & Lu, H. (2013). A comparison of physiologic modulators of fMRI signals. Human Brain Mapping, 34(9), 2078-2088.

Raz, N., Schmiedek, F., Rodrigue, K. M., Kennedy, K. M., Lindenberger, U., & Lövdén, M. (2013). Differential Brain Shrinkage Over Six Months Shows  Limited Association with Cognitive Practice. Brain and Cognition, 82, 171-180.

Park, H., Kennedy, K. M., Rodrigue, K. M., Hebrank, A. C., & Park, D. C. (2013). An fMRI study of episodic encoding across the lifespan: Changes in subsequent memory effects are evident by middle-age. Neuropsychologia, 51, 448-456. 

Rodrigue, K. M., Rieck, J. R., Kennedy, K. M., Devous, M. D., Diaz-Arrastia, R., Park, D. C.(2013). Risk Factors for Amyloid Deposition in Healthy Aging: Interactive Effects of Vascular and Genetic Risk.  JAMA Neurology, 70(5), 600-6.

Rodrigue, K.M., Daughtery, A., Haacke, E. M., & Raz, N. (2013).  The role of hippocampal iron concentration and hippocampal volume in age-related differences in memory.Cerebral Cortex, 23(7),1533-1541.

 


2012

Kennedy, K. M., Rodrigue, K.M., Devous, M. D., Sr., Hebrank, A. C., Bischof, G. N.,  & Park, D. C. (2012). Beta-Amyloid Burden is Associated with Altered Functional Activation During Encoding Across the Adult Lifespan. NeuroImage, 62(1), 1-8.

Park, J., Carp, J., Kennedy, K. M., Rodrigue, K. M., Bischof, G. N., Huang, C. M., Rieck, J. R., Polk, T., & Park, D. C. (2012). Neural broadening or neural attenuation?  Age-related dedifferentiation in the face network in a large lifespan sample. Journal of Neuroscience, 32, 2154-2158.

Rodrigue, K. M., Kennedy, K. M., Devous, M. D., Sr., Rieck, J. R., Hebrank, A. C., Diaz-Arrastia, R., Mathews, D., & Park, D. C. (2012). β-Amyloid Deposition in Healthy Aging: Regional Deposition and Cognitive Consequences. Neurology, 78, 387-395.

 


2011

Rodrigue, K. M., Haacke, E. M., Raz, N. (2011). Differential effects of age and history of hypertension on regional brain volumes and iron. NeuroImage, 54(2), 750-759.

Rodrigue, K. M.  & Kennedy, K. M. (2011). The cognitive consequences of structural changes to the aging brain. In K. W. Schaie, S. L. Willis (Eds.) Handbook of the Psychology of Aging, 7th ed., Ch 5, 73-92, New York: Elsevier.

Lu, H., Xu, F., Rodrigue, K. M., Kennedy, K. M., Cheng, Y., Flicker, B., Hebrank, A. C., Uh, J., & Park, D. C. (2011). Alterations in cerebral metabolic rate and vascular function across the adult lifespan. Cerebral Cortex, 21, 1426-1434.

Shing, Y. L., Rodrigue, K. M., Kennedy, K. M., Fandakova, Y., Bodammer, N., Werkle-Bergner, M., Lindenberger, U., Raz, N. (2011). Hippocampal subfield volumes: Age, vascular risk, and correlation with associative memory. Frontiers in Aging Neuroscience, Feb 4;3:2. PMC3035014.

Raz, N., Yang, Y., Rodrigue, K. M., Kennedy, K. M., Lindenberger, U., & Ghisletta, P. (2011). White Matter Deterioration in 15 months: Latent Growth Curve Models in Healthy Adults. Neurobiology of Aging,  doi:10.1016/j.neurobiolaging.2010.11.018.

Raz, N., Dahle, C. L., Rodrigue, K. M., Kennedy, K. M., & Land, S. (2011).  Effects of age, genes, and pulse pressure on executive functions in healthy adults. Neurobiology of Aging, 32, 1124–1137.

 


2010

Raz, N., Ghisletta, P., Rodrigue, K. M., Kennedy, K. M., & Lindenberger, U. (2010). Trajectories of brain aging in middle-aged and older adults: Regional and individual differences. NeuroImage, 51, 501–511.

Ghisletta, P., Kennedy, K. M., Rodrigue, K.M., Lindenberger, U., & Raz, N. (2010). Adult age differences and the role of cognitive resources in perceptual-motor skill acquisition: Application of a multilevel negative exponential model. Journals of Gerontology: Psychological Sciences, 65B, (2), 163-173.

 


2009

Rodrigue, K. M., Kennedy, K.M., & Park, D. C. (2009). Beta-amyloid deposition and the aging brain. Neuropsychology Review, 19, 436-450.

Kennedy, K. M., Rodrigue, K. M., Land, S., & Raz, N. (2009). BDNF val66met polymorphism influences age differences in microstructure of the corpus callosum. Frontiers in Human Neuroscience, 3:19. doi:10.3389/neuro.09.019.2009.

Raz, N., Dahle, C. L., Rodrigue, K. M., Kennedy, K. M., & Land, S. (2009).  Effects of age, genes, and pulse pressure on executive functions in healthy adults. Neurobiology of Aging doi:10.1016/j.neurobiolaging.2009.05.015.

Kennedy, K.M., Rodrigue, K.M., Head, D., Gunning-Dixon, F., & Raz, N. (2009). Neuroanatomical and cognitive mediators of age-related differences in perceptual priming and learning. Neuropsychology, 23(4), 475–491.

Head, D., Kennedy, K. M., Rodrigue, K. M., & Raz, N. (2009). Age-Differences in Perseveration: Cognitive and Neuroanatomical Mediators of Performance on the Wisconsin Card Sorting Test. Neuropsychologia, 47(4), 1200-1203.   

Deshmukh, A. B., Rodrigue, K. M., Kennedy, K. M., Land, S., Jacobs, B. S., & Raz, N. (2009). Synergistic Effects of the MTHFR C677T Polymorphism and Hypertension on Spatial Navigation. Biological Psychology, 80, 240-245.    

Raz, N., Rodrigue, K. M., Kennedy, K. M., & Land, S. (2009). Genetic and Vascular Modifiers of Age-Sensitive Cognitive Skills: Effects of COMT, BDNF, ApoE and Hypertension. Neuropsychology, 23(1), 105-116.

Kennedy, K. M., Erickson, K. I., Rodrigue, K. M., Voss, M. W., Colcombe, S. J., Kramer, A. F., Acker, J. D., & Raz, N. (2009). Age-Related Differences in Regional Brain Volumes: A Comparison of Optimized Voxel-Based Morphometry to Manual Volumetry. Neurobiology of Aging, 30(10), 1657-1676.

 


2008 and earlier

Head, D., Rodrigue, K. M., Kennedy, K.M., & Raz, N. (2008). Neuroanatomical and Cognitive Mediators of Age-Related Differences in Episodic Memory. Neuropsychology (22)4, 491-507.

Raz, N., Lindenberger, U., Ghisletta, P., Rodrigue, K. M., Kennedy, K. M., & Acker, J. D. (2007). Neuroanatomical Correlates of Fluid Intelligence in Healthy Adults and Persons with Vascular Risk Factors. Cerebral Cortex. 18, 718-726.

Raz, N., Rodrigue, K. M., Kennedy, K. M., & Acker, J. D. (2007). Vascular Health and Longitudinal Changes in Brain and Cognition in Middle-Aged and Older Adults. Neuropsychology, 21(2), 149-157.

Kennedy, K. M., Rodrigue, K. M., & Raz, N. (2007). Fragmented Pictures Revisited: Long-term Changes in Repetition Priming, Relation to Skill Learning, and the Role of Cognitive Resources. Gerontology, 53(3), 148-158.

Moffat, S. D., Kennedy, K. M., Rodrigue, K. M., & Raz, N. (2007). Age-Differences in Human Spatial Navigation: Extra-Hippocampal Contributions. Cerebral Cortex, 17, 1274-1282.

Raz, N., Rodrigue, K. M., Haacke, E. M. (2007). Brain Aging and its Modifiers: Insights from in vivo neuromorphometry and Susceptibility Weighted Imaging. Annals of the New York Academy of Sciences, 1097, 84-93.

Raz, N. & Rodrigue, K. M.  (2006). Differential Aging of the Brain: patterns cognitive correlates, modifiers. Neuroscience and Biobehavioral Reviews, 30(6), 730-748.

Rodrigue, K. M., Kennedy, K. M., & Raz, N. (2005). Aging and longitudinal change in perceptual-motor skill acquisition in healthy adults. Journal of Gerontology: Psychological Science, 60(4), P174-P181.

Raz, N., Lindenberger, U., Rodrigue, K. M., Kennedy, K. M., Head, D., Williamson, A., Dahle, C., Gerstorf, D. & Acker, J.D. (2005). Regional Brain Changes in Aging Healthy Adults: General Trends, Individual Differences, and Modifiers. Cerebral Cortex, 15, 1676-1689.

Raz, N.  Rodrigue K. M., Kennedy, K. M., Acker, J. D. (2004). Hormone replacement therapy and age-related brain shrinkage: Regional effects, Neuroreport, 15 (16), 2531-2534.

Rodrigue, K. M.  & Raz, N. (2004). Shrinkage of the entorhinal cortex over five years predicts memory performance in healthy adults, Journal of Neuroscience, 24(4), 956-963.

Raz, N., Rodrigue, K. M., Head, D., Kennedy, K. M., & Acker, J. D. (2004). Differential Changes in the Medial Temporal Structures: A Five-Year Longitudinal Study. Neurology, 62 (3) 433-438.

Raz, N., Gunning-Dixon, F., Head, D., Rodrigue, K. M., Williamson, A., & Acker, J. D. (2004). Regional volumetry of the cerebral cortex in normal adults: differential aging, sexual dimorphism, and hemispheric asymmetry. Neurobiology of Aging, (25), 377-396.

Raz, N., Rodrigue, K. M., & Acker, J. D. (2003). Hypertension and the Brain: Vulnerability of the Prefrontal Regions and Executive Function. Behavioral Neuroscience, 117(6), 1169-1180.

Raz, N., Rodrigue, K. M., Kennedy, K. M., Head, D., Gunning-Dixon, F., Acker, J. D. (2003). Aging of the Human Striatum: Longitudinal Evidence. American Journal of Neuroradiology, 24, 1849-1856.

Raz, N., Rodrigue, K. M., Kennedy, K. M., Dahle, C., Head, D., & Acker, J. D. (2003).  Differential Age-Related Changes in the Regional Metencephalic Volumes in Humans: A five year follow-up. Neuroscience Letters, 349(3), 163-166.

Buskist, W., Tears, R. S., Davis, S. F., & Rodrigue, K. M.  (2002). The teaching of psychology course: Prevalence and content. Teaching of Psychology, 29, 140-142.

Kennedy, K. M., Rodrigue, K. M., & Davis, S. F. (2000). So you want to teach less in hopes of teaching more? College Student Journal, 34(4), 626-632.

Davis, S. F., Smith, B. G., Rodrigue, K. M., & Pulvers, K. (1999).  An examination of internet usage on two college campuses. College Student Journal, 33, 257-260.