Karen M. Rodrigue, Ph. D.
Assistant Professor of Behavioral and Brain Sciences

Center for Vital Longevity
1600 Viceroy Drive,
Suite 800




Horn, M. M., Kennedy, K. M., & Rodrigue, K. M. (in press). Association between subjective memory assessment and associative memory performance: Role of AD risk factors. Psychology and Aging, Special Issue on Age-Related Differences in Associative Memory: Empirical Evidence and Theoretical Perspectives.

Kennedy, K. M., Boylan, M. A., Rieck, J. R., Foster, C. M., & Rodrigue, K. M. (2017). Dynamic range in BOLD modulation: Lifespan aging trajectories and association with performance. Neurobiology of Aging, 60, 153-163. (DOI: 10.1016/j.neurobiolaging.2017.08.027)

Foster, C. M., Kennedy, K. M., & Rodrigue, K. M. (2017). Differential aging trajectories of modulation of activation to cognitive challenge in APOE ε4 groups: Reduced modulation predicts poorer cognitive performance. Journal of Neuroscience37(29), 6894-6901. (DOI: 10.1523/JNEUROSCI.3900-16.2017)

Farrell, M.E., Kennedy, K.M., Rodrigue, K.M., Wig, G., Bischof, G.N., Rieck, J.R., Chen, X., Festini, S.B., Devous, M.D., & Park, D.C. (2017) Association of longitudinal cognitive decline with amyloid burden in middle-aged and older adults: Evidence for a dose-response relationship. JAMA Neurology, 74(7), 830-838. doi: 10.1001/jamaneurol.2017.0892. (DOI: 10.1001/jamaneurol.2017.0892)

*Rast, P., *Kennedy, K. M., Rodrigue, K. M., Robinson, P.R.A.W., Gross, A.L., McClaren, D.G., Grabowski, T., Schaie, K.W., & Willis, S. L. (2017). APOEε4 Genotype and Hypertension Modify 8-year Cortical Thinning: Five Occasion Evidence from the Seattle Longitudinal Study. Cerebral Cortex, in press. *Shared first authorship. (DOI: 10.1093/cercor/bhx099)

Rieck, J. R., Rodrigue, K. M., Boylan, M. A., & Kennedy, K. M. (2017). Age-related Reduction of BOLD Modulation to Cognitive Difficulty Predicts Poorer Task Accuracy and Poorer Fluid Reasoning Ability. NeuroImage, 147, 262-271. (DOI: 10.1016/j.neuroimage.2016.12.022)

Kennedy, K. M., Rieck, J. R., Boylan, M. A., & Rodrigue, K. M. (2017). Functional magnetic resonance imaging data of incremental increases in visuo-spatial difficulty in a large adult lifespan sample. Data in Brief, 11, 54-60. (DOI: 10.1016/j.dib.2017.01.004)

Rodrigue, K. M. & Bischof, G. (2017). The modifying role of hypertension in cognitive and brain aging. In R. Cabeza, L. Nyberg, & D.C. Park (Eds.), Cognitive Neuroscience of Aging, 2nd Edition, (389-414). New York, NY: Oxford University Press. (DOI: 10.1093/acprof:oso/9780199372935.003.0016)


Wisse, L. E. M., Daugherty, A. M., Olsen, R. K., Berron, D., Carr, V. A., Stark, C. E. L., Amaral, R. S. C., Amunts, K., Augustinack, J. C., Bender, A. R., Bernstein, J. D., Boccardi, M., Bocchetta, M., Burggren, A., Chakravarty, M. M., Chupin, M., Ekstrom, A., de Flores, R., Insausti, R., Kanel, P., Kedo, O., Kennedy, K. M., Kerchner, G. A., LaRocque, K., Liu, X., Maass, A., Malykhin, N., Mueller, S. G., Ofen, N., Palombo, D. J., Parekh, M. B., Pluta, J. B., Pruessner, J. C., Raz, N., Rodrigue, K. M., Schoemaker, D., Shafer, A. T., Steve, T. A., Suthana, N., Wang, L., Winterburn, J. L., Yassa, M. A., Yushkevich, P. A., & la Joie, R., for the Hippocampal Subfields Group (2016). A harmonized segmentation protocol for hippocampal and parahippocampal subregions: Why do we need one and what are the key goals? Hippocampus, 27(1), 3-11. (DOI: 10.1002/hipo.22671)

Bischof, G. N., Rodrigue, K. M., Kennedy, K. M., Devous, M. D., & Park, D. C. (2016). Amyloid deposition in younger adults is linked to episodic memory performance. Neurology, 87(24), 2562-2566. (DOI: 10.1212/WNL.0000000000003425)

McDonough, I. M., Bischof, G. N., Kennedy, K. M., Rodrigue, K. M., Farrell, M. E., & Park, D. C. (2016). Discrepancies between Fluid and Crystallized Ability in Healthy Adults: A Behavioral Marker of Preclinical Alzheimer’s Disease. Neurobiology of Aging, 46, 68-75. (DOI: 10.1016/j.neurobiolaging.2016.06.011)


Kennedy, K. M., Reese, E., Horn, M., Sizemore, A., Unni, A., Meerbrey, M., Kalich, A., & Rodrigue, K. M. (2015). BDNF val66met Polymorphism Affects Aging of Multiple Types of Memory. Brain Research, Special Issue on Memory and Aging,1612, 104-117. (DOI: 10.1016/j.brainres.2014.09.044)

Kennedy, K. M., Rodrigue, K. M., Bischof, G. N., Hebrank, A. C., Reuter-Lorenz, P. A., & Park, D. C. (2015). Age Trajectories of Functional Activation Under Conditions of Low and High Processing Demands: An Adult Lifespan fMRI Study of the Aging Brain. NeuroImage, 104, 21-34. (DOI: 10.1016/j.neuroimage.2014.09.056)

Rieck, J. R., Rodrigue, K. M., Kennedy, K. M., Devous, M. D., Sr., & Park, D. C. (2015). The effect of beta-amyloid on face processing in young and old adults: A multivariate analysis of the BOLD signal. Human Brain Mapping, 36(7), 2514-2526. (DOI: 10.1002/hbm.22788)


Rodrigue, K.M. (2013). Contribution of Cerebrovascular Health to the Diagnosis of Alzheimer Disease. JAMA Neurology, 70(4),438-439. (DOI: 10.1001/jamaneurol.2013.1862)

Liu, P., Hebrank, A. C., Rodrigue, K. M., Kennedy, K. M., Section, J., Park, D. C., & Lu, H. (2013). Age-related differences in memory-encoding fMRI responses after accounting for decline in vascular reactivity.  NeuroImage, 78, 415-425. (DOI: 10.1016/j.neuroimage.2013.04.053)

Liu, P., Hebrank, A. C., Rodrigue, K. M., Kennedy, K. M., Park. D. C., & Lu, H. (2013). A comparison of physiologic modulators of fMRI signals. Human Brain Mapping, 34(9), 2078-2088. (DOI: 10.1002/hbm.22053)

Raz, N., Schmiedek, F., Rodrigue, K. M., Kennedy, K. M., Lindenberger, U., & Lövdén, M. (2013). Differential Brain Shrinkage Over Six Months Shows  Limited Association with Cognitive Practice. Brain and Cognition, 82, 171-180. (DOI: 10.1016/j.bandc.2013.04.002)

Park, H., Kennedy, K. M., Rodrigue, K. M., Hebrank, A. C., & Park, D. C. (2013). An fMRI study of episodic encoding across the lifespan: Changes in subsequent memory effects are evident by middle-age. Neuropsychologia, 51, 448-456. (DOI: 10.1016/j.neuropsychologia.2012.11.025)

Rodrigue, K. M., Rieck, J. R., Kennedy, K. M., Devous, M. D., Diaz-Arrastia, R., & Park, D. C.(2013). Risk Factors for Amyloid Deposition in Healthy Aging: Interactive Effects of Vascular and Genetic Risk. JAMA Neurology, 70(5), 600-6. (DOI: 10.1001/jamaneurol.2013.1342)

Rodrigue, K.M., Daughtery, A., Haacke, E. M., & Raz, N. (2013). The role of hippocampal iron concentration and hippocampal volume in age-related differences in memory.Cerebral Cortex, 23(7),1533-1541. (DOI: 10.1093/cercor/bhs139)


Lövdén, M., Schmiedek, F., Kennedy, K. M., Rodrigue, K.M., Raz, N., & Lindenberger, U. (2012). Does Variability in Cognitive Performance Correlate with Frontal Brain Volume? NeuroImage, 64(1), 209-215. (DOI: 10.1016/j.neuroimage.2012.09.039)

Kennedy, K. M., Rodrigue, K.M., Devous, M. D., Sr., Hebrank, A. C., Bischof, G. N.,  & Park, D. C. (2012). Effects of beta-amyloid accumulation on neural function during encoding across the adult lifespan. NeuroImage, 62 (1), 1-8. (DOI: 10.1016/j.neuroimage.2012.03.077)

Park, J., Carp, J., Kennedy, K. M., Rodrigue, K. M., Bischof, G. N., Huang, C. M., Rieck, J. R., Polk, T., & Park, D. C. (2012). Neural Broadening or Neural Attenuation? Investigating Age-Related Dedifferentiation in the Face Network in a Large Lifespan Sample. Journal of Neuroscience, 32, 2154-2158. (DOI: 10.1523/JNEUROSCI.4494-11.2012)

Rodrigue, K. M., Kennedy, K. M., Devous, M. D., Sr., Rieck, J. R., Hebrank, A. C., Diaz-Arrastia, R., Mathews, D., & Park, D. C. (2012). β-Amyloid Burden in Healthy Aging: Regional Distribution and Cognitive Consequences. Neurology, 78, 387-395. (DOI: 10.1212/WNL.0b013e318245d295)

Raz, N., Yang, Y., Rodrigue, K. M., Kennedy, K. M., Lindenberger, U., & Ghisletta, P. (2012). White Matter Deterioration in 15 months: Latent Growth Curve Models in Healthy Adults. Neurobiology of Aging, 33(2), 429.e1–429.e5. (DOI: 10.1016/j.neurobiolaging.2010.11.018)


Rodrigue, K. M., Haacke, E. M., & Raz, N. (2011). Differential effects of age and history of hypertension on regional brain volumes and iron. NeuroImage, 54(2), 750-759. (DOI: 10.1016/j.neuroimage.2010.09.068)

Rodrigue, K. M. & Kennedy, K. M. (2011). The cognitive consequences of structural changes to the aging brain. In K. W. Schaie, S. L. Willis (Eds.) Handbook of the Psychology of Aging, 7th ed., Ch 5, 73-92, New York: Elsevier (DOI: 10.13140/2.1.1430.6247)

Lu, H., Xu, F., Rodrigue, K. M., Kennedy, K. M., Cheng, Y., Flicker, B., Hebrank, A. C., Uh, J., & Park, D. C. (2011). Alterations in cerebral metabolic rate and vascular function across the adult lifespan. Cerebral Cortex, 21, 1426-1434. (DOI: 10.1093/cercor/bhq224)

Shing, Y. L., Rodrigue, K. M., Kennedy, K. M., Fandakova, Y., Bodammer, N., Werkle-Bergner, M., Lindenberger, U., & Raz, N. (2011). Hippocampal subfield volumes: Age, vascular risk, and correlation with associative memory. Frontiers in Aging Neuroscience, Feb 4;3:2. (DOI: 10.3389/fnagi.2011.00002)

Raz, N., Dahle, C. L., Rodrigue, K. M., Kennedy, K. M., & Land, S. (2011).  Effects of age, genes, and pulse pressure on executive functions in healthy adults. Neurobiology of Aging, 32, 1124–1137. (DOI: 10.1016/j.neurobiolaging.2009.05.015)


Raz, N., Ghisletta, P., Rodrigue, K. M., Kennedy, K. M., & Lindenberger, U. (2010). Trajectories of brain aging in middle-aged and older adults: Regional and individual differences. NeuroImage, 51, 501–511. (DOI: 10.1016/j.neuroimage.2010.03.020)

Ghisletta, P., Kennedy, K. M., Rodrigue, K.M., Lindenberger, U., & Raz, N. (2010). Adult age differences and the role of cognitive resources in perceptual-motor skill acquisition: Application of a multilevel negative exponential model. Journals of Gerontology: Psychological Sciences, 65B, (2), 163-173. (DOI: 10.1093/geronb/gbp126)


Rodrigue, K. M., Kennedy, K.M., & Park, D. C. (2009). Beta-amyloid deposition and the aging brain. Neuropsychology Review, 19, 436-450. (DOI: 10.1007/s11065-009-9118-x)

Kennedy, K. M., Rodrigue, K. M., Land, S., & Raz, N. (2009). BDNF val66met polymorphism influences age differences in microstructure of the corpus callosum. Frontiers in Human Neuroscience, 3:19. doi:10.3389/neuro.09.019.2009. (DOI: 10.3389/neuro.09.019.2009)

Kennedy, K.M., Rodrigue, K.M., Head, D., Gunning-Dixon, F., & Raz, N. (2009). Neuroanatomical and cognitive mediators of age-related differences in perceptual priming and learning. Neuropsychology, 23(4), 475–491. (DOI: 10.1037/a0015377)

Head, D., Kennedy, K. M., Rodrigue, K. M., & Raz, N. (2009). Age Differences in Perseveration: Cognitive and Neuroanatomical Mediators of Performance on the Wisconsin Card Sorting Test. Neuropsychologia, 47(4), 1200-1203. (DOI: 10.1016/j.neuropsychologia.2009.01.003)

Deshmukh, A. B., Rodrigue, K. M., Kennedy, K. M., Land, S., Jacobs, B. S., & Raz, N. (2009). Synergistic Effects of the MTHFR C677T Polymorphism and Hypertension on Spatial Navigation. Biological Psychology, 80, 240-245. (DOI: 10.1016/j.biopsycho.2008.10.003)

Raz, N., Rodrigue, K. M., Kennedy, K. M., & Land, S. (2009). Genetic and Vascular Modifiers of Age-Sensitive Cognitive Skills: Effects of COMT, BDNF, ApoE and Hypertension. Neuropsychology, 23(1), 105-116. (DOI: 10.1037/a0013487)

Kennedy, K. M., Erickson, K. I., Rodrigue, K. M., Voss, M. W., Colcombe, S. J., Kramer, A. F., Acker, J. D., & Raz, N. (2009). Age-Related Differences in Regional Brain Volumes: A Comparison of Optimized Voxel-Based Morphometry to Manual Volumetry. Neurobiology of Aging, 30(10), 1657-1676. (DOI: 10.1016/j.neurobiolaging.2007.12.020)

2008 and earlier

Raz, N., Dahle, C. L., Rodrigue, K. M., Kennedy, K. M., Land, S., & Jacobs, B. S. (2008). Brain-Derived Neurotrophic Factor Val66Met and blood glucose: A synergistic effect on memory. Frontiers in Human Neuroscience, 2:12. (DOI: 10.3389/neuro.09.012.2008)

Head, D., Rodrigue, K. M., Kennedy, K. M., & Raz, N. (2008). Neuroanatomical and Cognitive Mediators of Age-Related Differences in Episodic Memory. Neuropsychology (22)4, 491-507. (DOI: 10.1037/0894-4105.22.4.491)

Raz, N., Lindenberger, U., Ghisletta, P., Rodrigue, K. M., Kennedy, K. M., & Acker, J. D. (2007). Neuroanatomical Correlates of Fluid Intelligence in Healthy Adults and Persons with Vascular Risk Factors. Cerebral Cortex. 18, 718-726. (DOI: 10.1093/cercor/bhm108)

Raz, N., Rodrigue, K. M., Kennedy, K. M., & Acker, J. D. (2007). Vascular Health and Longitudinal Changes in Brain and Cognition in Middle-Aged and Older Adults. Neuropsychology, 21(2), 149-157. (DOI: 10.1037/0894-4105.21.2.149)

Kennedy, K. M., Rodrigue, K. M., & Raz, N. (2007). Fragmented Pictures Revisited: Long-term Changes in Repetition Priming, Relation to Skill Learning, and the Role of Cognitive Resources. Gerontology, 53(3), 148-158. (DOI: 10.1159/000098029)

Moffat, S. D., Kennedy, K. M., Rodrigue, K. M., & Raz, N. (2007). Extrahippocampal Contributions to Age Differences in Human Spatial Navigation. Cerebral Cortex, 17, 1274-1282. (DOI: 10.1093/cercor/bhl036)

Raz, N., Rodrigue, K. M., & Haacke, E. M. (2007). Brain Aging and its Modifiers: Insights from in vivo neuromorphometry and Susceptibility Weighted Imaging. Annals of the New York Academy of Sciences, 1097, 84-93. (DOI: 10.1196/annals.1379.018)

Raz, N. & Rodrigue, K. M. (2006). Differential Aging of the Brain: patterns cognitive correlates, modifiers. Neuroscience and Biobehavioral Reviews, 30(6), 730-748.

(DOI: 10.1016/j.neubiorev.2006.07.001)

Rodrigue, K. M., Kennedy, K. M., & Raz, N. (2005). Aging and longitudinal change in perceptual-motor skill acquisition in healthy adults. Journal of Gerontology: Psychological Science, 60(4), P174-P181. (DOI: 10.1093/geronb/60.4.P174)

Raz, N., Lindenberger, U., Rodrigue, K. M., Kennedy, K. M., Head, D., Williamson, A., Dahle, C., Gerstorf, D. & Acker, J.D. (2005). Regional Brain Changes in Aging Healthy Adults: General Trends, Individual Differences, and Modifiers. Cerebral Cortex, 15(11), 1676-1689. (DOI: 10.1093/cercor/bhi044)

Raz, N. Rodrigue K. M., Kennedy, K. M., Acker, J. D. (2004). Hormone replacement therapy and age-related brain shrinkage: Regional effects, Neuroreport, 15 (16), 2531-2534. (DOI: 10.1097/00001756-200411150-00020)

Rodrigue, K. M. & Raz, N. (2004). Shrinkage of the entorhinal cortex over five years predicts memory performance in healthy adults, Journal of Neuroscience, 24(4), 956-963. (DOI: 10.1523/JNEUROSCI.4166-03.2004)

Raz, N., Rodrigue, K. M., Head, D., Kennedy, K. M., & Acker, J. D. (2004). Differential aging of the medial temporal lobe: A study of a five-year change. Neurology, 62 (3) 433-438. (DOI: 10.1212/01.WNL.0000106466.09835.46)

Raz, N., Gunning-Dixon, F., Head, D., Rodrigue, K. M., Williamson, A., & Acker, J. D. (2004). Aging, sexual dimorphism, and hemispheric asymmetry of the cerebral cortex: replicability of regional differences in volume. Neurobiology of Aging, (25), 377-396. (DOI: 10.1016/S0197-4580(03)00118-0)

Raz, N., Rodrigue, K. M., & Acker, J. D. (2003). Hypertension and the Brain: Vulnerability of the Prefrontal Regions and Executive Functions. Behavioral Neuroscience, 117(6), 1169-1180. (DOI: 10.1037/0735-7044.117.6.1169)

Raz, N., Rodrigue, K. M., Kennedy, K. M., Head, D., Gunning-Dixon, F., & Acker, J. D. (2003). Differential aging of the human striatum: Longitudinal evidence. American Journal of Neuroradiology, 24, 1849-1856. (PMID: 14561615)

Raz, N., Rodrigue, K. M., Kennedy, K. M., Dahle, C., Head, D., & Acker, J. D. (2003).  Differential Age-Related Changes in the Regional Metencephalic Volumes in Humans: A five year follow-up. Neuroscience Letters, 349(3), 163-166. (DOI: 10.1016/S0304-3940(03)00820-6)

Buskist, W., Tears, R. S., Davis, S. F., & Rodrigue, K. M. (2002). The teaching of psychology course: Prevalence and content. Teaching of Psychology, 29, 140-142.

Kennedy, K. M., Rodrigue, K. M., & Davis, S. F. (2000). So you want to teach less in hopes of teaching more? College Student Journal, 34(4), 626-632.

Davis, S. F., Smith, B. G., Rodrigue, K. M., & Pulvers, K. (1999).  An examination of internet usage on two college campuses. College Student Journal, 33, 257-260.