Karen M. Rodrigue, Ph. D.
Assistant Professor of Behavioral and Brain Sciences

Center for Vital Longevity
1600 Viceroy Drive,
Suite 800




Foster, C. M., Kennedy, K. M., Hoagey, D. A., Horn, M. M., Rodrigue, K. M. (2018). Both hyper- and hypo-activation to cognitive challenge are associated with increased beta-amyloid deposition in healthy aging: A nonlinear effect. NeuroImage, 166, 285-292. (DOI:10.1016/j.neuroimage.2017.10.068 )

Horn, M. M., Kennedy, K. M., Rodrigue, K. M. (2018). Association between subjective memory assessment and associative memory performance: Role of AD risk factors. Psychology and Aging, 33(1), 109-118.

*Rast, P., *Kennedy, K. M., Rodrigue, K. M., Robinson, P.R.A.W., Gross, A.L., McClaren, D.G., Grabowski, T., Schaie, K.W., & Willis, S. L. (2017). APOEε4 Genotype and Hypertension Modify 8-year Cortical Thinning: Five Occasion Evidence from the Seattle Longitudinal Study. Cerebral Cortex, 28(6), 1934-1945. *Shared first authorship. (DOI: 10.1093/cercor/bhx099)


Kennedy, K. M., Boylan, M. A., Rieck, J. R., Foster, C. M., & Rodrigue, K. M. (2017). Dynamic range in BOLD modulation: Lifespan aging trajectories and association with performance. Neurobiology of Aging, 60, 153-163. (DOI: 10.1016/j.neurobiolaging.2017.08.027)

Foster, C. M., Kennedy, K. M., & Rodrigue, K. M. (2017). Differential aging trajectories of modulation of activation to cognitive challenge in APOE ε4 groups: Reduced modulation predicts poorer cognitive performance. Journal of Neuroscience37(29), 6894-6901. (DOI: 10.1523/JNEUROSCI.3900-16.2017)

Farrell, M.E., Kennedy, K.M., Rodrigue, K.M., Wig, G., Bischof, G.N., Rieck, J.R., Chen, X., Festini, S.B., Devous, M.D., & Park, D.C. (2017) Association of longitudinal cognitive decline with amyloid burden in middle-aged and older adults: Evidence for a dose-response relationship. JAMA Neurology, 74(7), 830-838. doi: 10.1001/jamaneurol.2017.0892. (DOI: 10.1001/jamaneurol.2017.0892)

Rieck, J. R., Rodrigue, K. M., Boylan, M. A., & Kennedy, K. M. (2017). Age-related Reduction of BOLD Modulation to Cognitive Difficulty Predicts Poorer Task Accuracy and Poorer Fluid Reasoning Ability. NeuroImage, 147, 262-271. (DOI: 10.1016/j.neuroimage.2016.12.022)

Kennedy, K. M., Rieck, J. R., Boylan, M. A., & Rodrigue, K. M. (2017). Functional magnetic resonance imaging data of incremental increases in visuo-spatial difficulty in a large adult lifespan sample. Data in Brief, 11, 54-60. (DOI: 10.1016/j.dib.2017.01.004)

Rodrigue, K. M. & Bischof, G. (2017). The modifying role of hypertension in cognitive and brain aging. In R. Cabeza, L. Nyberg, & D.C. Park (Eds.), Cognitive Neuroscience of Aging, 2nd Edition, (389-414). New York, NY: Oxford University Press. (DOI: 10.1093/acprof:oso/9780199372935.003.0016)


Wisse, L. E. M., Daugherty, A. M., Olsen, R. K., Berron, D., Carr, V. A., Stark, C. E. L., Amaral, R. S. C., Amunts, K., Augustinack, J. C., Bender, A. R., Bernstein, J. D., Boccardi, M., Bocchetta, M., Burggren, A., Chakravarty, M. M., Chupin, M., Ekstrom, A., de Flores, R., Insausti, R., Kanel, P., Kedo, O., Kennedy, K. M., Kerchner, G. A., LaRocque, K., Liu, X., Maass, A., Malykhin, N., Mueller, S. G., Ofen, N., Palombo, D. J., Parekh, M. B., Pluta, J. B., Pruessner, J. C., Raz, N., Rodrigue, K. M., Schoemaker, D., Shafer, A. T., Steve, T. A., Suthana, N., Wang, L., Winterburn, J. L., Yassa, M. A., Yushkevich, P. A., & la Joie, R., for the Hippocampal Subfields Group (2016). A harmonized segmentation protocol for hippocampal and parahippocampal subregions: Why do we need one and what are the key goals? Hippocampus, 27(1), 3-11. (DOI: 10.1002/hipo.22671)

Bischof, G. N., Rodrigue, K. M., Kennedy, K. M., Devous, M. D., & Park, D. C. (2016). Amyloid deposition in younger adults is linked to episodic memory performance. Neurology, 87(24), 2562-2566. (DOI: 10.1212/WNL.0000000000003425)

McDonough, I. M., Bischof, G. N., Kennedy, K. M., Rodrigue, K. M., Farrell, M. E., & Park, D. C. (2016). Discrepancies between Fluid and Crystallized Ability in Healthy Adults: A Behavioral Marker of Preclinical Alzheimer’s Disease. Neurobiology of Aging, 46, 68-75. (DOI: 10.1016/j.neurobiolaging.2016.06.011)


Kennedy, K. M., Reese, E., Horn, M., Sizemore, A., Unni, A., Meerbrey, M., Kalich, A., & Rodrigue, K. M. (2015). BDNF val66met Polymorphism Affects Aging of Multiple Types of Memory. Brain Research, Special Issue on Memory and Aging,1612, 104-117. (DOI: 10.1016/j.brainres.2014.09.044)

Kennedy, K. M., Rodrigue, K. M., Bischof, G. N., Hebrank, A. C., Reuter-Lorenz, P. A., & Park, D. C. (2015). Age Trajectories of Functional Activation Under Conditions of Low and High Processing Demands: An Adult Lifespan fMRI Study of the Aging Brain. NeuroImage, 104, 21-34. (DOI: 10.1016/j.neuroimage.2014.09.056)

Rieck, J. R., Rodrigue, K. M., Kennedy, K. M., Devous, M. D., Sr., & Park, D. C. (2015). The effect of beta-amyloid on face processing in young and old adults: A multivariate analysis of the BOLD signal. Human Brain Mapping, 36(7), 2514-2526. (DOI: 10.1002/hbm.22788)


Rodrigue, K.M. (2013). Contribution of Cerebrovascular Health to the Diagnosis of Alzheimer Disease. JAMA Neurology, 70(4),438-439. (DOI: 10.1001/jamaneurol.2013.1862)

Liu, P., Hebrank, A. C., Rodrigue, K. M., Kennedy, K. M., Section, J., Park, D. C., & Lu, H. (2013). Age-related differences in memory-encoding fMRI responses after accounting for decline in vascular reactivity.  NeuroImage, 78, 415-425. (DOI: 10.1016/j.neuroimage.2013.04.053)

Liu, P., Hebrank, A. C., Rodrigue, K. M., Kennedy, K. M., Park. D. C., & Lu, H. (2013). A comparison of physiologic modulators of fMRI signals. Human Brain Mapping, 34(9), 2078-2088. (DOI: 10.1002/hbm.22053)

Raz, N., Schmiedek, F., Rodrigue, K. M., Kennedy, K. M., Lindenberger, U., & Lövdén, M. (2013). Differential Brain Shrinkage Over Six Months Shows  Limited Association with Cognitive Practice. Brain and Cognition, 82, 171-180. (DOI: 10.1016/j.bandc.2013.04.002)

Park, H., Kennedy, K. M., Rodrigue, K. M., Hebrank, A. C., & Park, D. C. (2013). An fMRI study of episodic encoding across the lifespan: Changes in subsequent memory effects are evident by middle-age. Neuropsychologia, 51, 448-456. (DOI: 10.1016/j.neuropsychologia.2012.11.025)

Rodrigue, K. M., Rieck, J. R., Kennedy, K. M., Devous, M. D., Diaz-Arrastia, R., & Park, D. C.(2013). Risk Factors for Amyloid Deposition in Healthy Aging: Interactive Effects of Vascular and Genetic Risk. JAMA Neurology, 70(5), 600-6. (DOI: 10.1001/jamaneurol.2013.1342)

Rodrigue, K.M., Daughtery, A., Haacke, E. M., & Raz, N. (2013). The role of hippocampal iron concentration and hippocampal volume in age-related differences in memory.Cerebral Cortex, 23(7),1533-1541. (DOI: 10.1093/cercor/bhs139)


Lövdén, M., Schmiedek, F., Kennedy, K. M., Rodrigue, K.M., Raz, N., & Lindenberger, U. (2012). Does Variability in Cognitive Performance Correlate with Frontal Brain Volume? NeuroImage, 64(1), 209-215. (DOI: 10.1016/j.neuroimage.2012.09.039)

Kennedy, K. M., Rodrigue, K.M., Devous, M. D., Sr., Hebrank, A. C., Bischof, G. N.,  & Park, D. C. (2012). Effects of beta-amyloid accumulation on neural function during encoding across the adult lifespan. NeuroImage, 62 (1), 1-8. (DOI: 10.1016/j.neuroimage.2012.03.077)

Park, J., Carp, J., Kennedy, K. M., Rodrigue, K. M., Bischof, G. N., Huang, C. M., Rieck, J. R., Polk, T., & Park, D. C. (2012). Neural Broadening or Neural Attenuation? Investigating Age-Related Dedifferentiation in the Face Network in a Large Lifespan Sample. Journal of Neuroscience, 32, 2154-2158. (DOI: 10.1523/JNEUROSCI.4494-11.2012)

Rodrigue, K. M., Kennedy, K. M., Devous, M. D., Sr., Rieck, J. R., Hebrank, A. C., Diaz-Arrastia, R., Mathews, D., & Park, D. C. (2012). β-Amyloid Burden in Healthy Aging: Regional Distribution and Cognitive Consequences. Neurology, 78, 387-395. (DOI: 10.1212/WNL.0b013e318245d295)

Raz, N., Yang, Y., Rodrigue, K. M., Kennedy, K. M., Lindenberger, U., & Ghisletta, P. (2012). White Matter Deterioration in 15 months: Latent Growth Curve Models in Healthy Adults. Neurobiology of Aging, 33(2), 429.e1–429.e5. (DOI: 10.1016/j.neurobiolaging.2010.11.018)


Rodrigue, K. M., Haacke, E. M., & Raz, N. (2011). Differential effects of age and history of hypertension on regional brain volumes and iron. NeuroImage, 54(2), 750-759. (DOI: 10.1016/j.neuroimage.2010.09.068)

Rodrigue, K. M. & Kennedy, K. M. (2011). The cognitive consequences of structural changes to the aging brain. In K. W. Schaie, S. L. Willis (Eds.) Handbook of the Psychology of Aging, 7th ed., Ch 5, 73-92, New York: Elsevier (DOI: 10.13140/2.1.1430.6247)

Lu, H., Xu, F., Rodrigue, K. M., Kennedy, K. M., Cheng, Y., Flicker, B., Hebrank, A. C., Uh, J., & Park, D. C. (2011). Alterations in cerebral metabolic rate and vascular function across the adult lifespan. Cerebral Cortex, 21, 1426-1434. (DOI: 10.1093/cercor/bhq224)

Shing, Y. L., Rodrigue, K. M., Kennedy, K. M., Fandakova, Y., Bodammer, N., Werkle-Bergner, M., Lindenberger, U., & Raz, N. (2011). Hippocampal subfield volumes: Age, vascular risk, and correlation with associative memory. Frontiers in Aging Neuroscience, Feb 4;3:2. (DOI: 10.3389/fnagi.2011.00002)

Raz, N., Dahle, C. L., Rodrigue, K. M., Kennedy, K. M., & Land, S. (2011).  Effects of age, genes, and pulse pressure on executive functions in healthy adults. Neurobiology of Aging, 32, 1124–1137. (DOI: 10.1016/j.neurobiolaging.2009.05.015)


Raz, N., Ghisletta, P., Rodrigue, K. M., Kennedy, K. M., & Lindenberger, U. (2010). Trajectories of brain aging in middle-aged and older adults: Regional and individual differences. NeuroImage, 51, 501–511. (DOI: 10.1016/j.neuroimage.2010.03.020)

Ghisletta, P., Kennedy, K. M., Rodrigue, K.M., Lindenberger, U., & Raz, N. (2010). Adult age differences and the role of cognitive resources in perceptual-motor skill acquisition: Application of a multilevel negative exponential model. Journals of Gerontology: Psychological Sciences, 65B, (2), 163-173. (DOI: 10.1093/geronb/gbp126)


Rodrigue, K. M., Kennedy, K.M., & Park, D. C. (2009). Beta-amyloid deposition and the aging brain. Neuropsychology Review, 19, 436-450. (DOI: 10.1007/s11065-009-9118-x)

Kennedy, K. M., Rodrigue, K. M., Land, S., & Raz, N. (2009). BDNF val66met polymorphism influences age differences in microstructure of the corpus callosum. Frontiers in Human Neuroscience, 3:19. doi:10.3389/neuro.09.019.2009. (DOI: 10.3389/neuro.09.019.2009)

Kennedy, K.M., Rodrigue, K.M., Head, D., Gunning-Dixon, F., & Raz, N. (2009). Neuroanatomical and cognitive mediators of age-related differences in perceptual priming and learning. Neuropsychology, 23(4), 475–491. (DOI: 10.1037/a0015377)

Head, D., Kennedy, K. M., Rodrigue, K. M., & Raz, N. (2009). Age Differences in Perseveration: Cognitive and Neuroanatomical Mediators of Performance on the Wisconsin Card Sorting Test. Neuropsychologia, 47(4), 1200-1203. (DOI: 10.1016/j.neuropsychologia.2009.01.003)

Deshmukh, A. B., Rodrigue, K. M., Kennedy, K. M., Land, S., Jacobs, B. S., & Raz, N. (2009). Synergistic Effects of the MTHFR C677T Polymorphism and Hypertension on Spatial Navigation. Biological Psychology, 80, 240-245. (DOI: 10.1016/j.biopsycho.2008.10.003)

Raz, N., Rodrigue, K. M., Kennedy, K. M., & Land, S. (2009). Genetic and Vascular Modifiers of Age-Sensitive Cognitive Skills: Effects of COMT, BDNF, ApoE and Hypertension. Neuropsychology, 23(1), 105-116. (DOI: 10.1037/a0013487)

Kennedy, K. M., Erickson, K. I., Rodrigue, K. M., Voss, M. W., Colcombe, S. J., Kramer, A. F., Acker, J. D., & Raz, N. (2009). Age-Related Differences in Regional Brain Volumes: A Comparison of Optimized Voxel-Based Morphometry to Manual Volumetry. Neurobiology of Aging, 30(10), 1657-1676. (DOI: 10.1016/j.neurobiolaging.2007.12.020)

2008 and earlier

Raz, N., Dahle, C. L., Rodrigue, K. M., Kennedy, K. M., Land, S., & Jacobs, B. S. (2008). Brain-Derived Neurotrophic Factor Val66Met and blood glucose: A synergistic effect on memory. Frontiers in Human Neuroscience, 2:12. (DOI: 10.3389/neuro.09.012.2008)

Head, D., Rodrigue, K. M., Kennedy, K. M., & Raz, N. (2008). Neuroanatomical and Cognitive Mediators of Age-Related Differences in Episodic Memory. Neuropsychology (22)4, 491-507. (DOI: 10.1037/0894-4105.22.4.491)

Raz, N., Lindenberger, U., Ghisletta, P., Rodrigue, K. M., Kennedy, K. M., & Acker, J. D. (2007). Neuroanatomical Correlates of Fluid Intelligence in Healthy Adults and Persons with Vascular Risk Factors. Cerebral Cortex. 18, 718-726. (DOI: 10.1093/cercor/bhm108)

Raz, N., Rodrigue, K. M., Kennedy, K. M., & Acker, J. D. (2007). Vascular Health and Longitudinal Changes in Brain and Cognition in Middle-Aged and Older Adults. Neuropsychology, 21(2), 149-157. (DOI: 10.1037/0894-4105.21.2.149)

Kennedy, K. M., Rodrigue, K. M., & Raz, N. (2007). Fragmented Pictures Revisited: Long-term Changes in Repetition Priming, Relation to Skill Learning, and the Role of Cognitive Resources. Gerontology, 53(3), 148-158. (DOI: 10.1159/000098029)

Moffat, S. D., Kennedy, K. M., Rodrigue, K. M., & Raz, N. (2007). Extrahippocampal Contributions to Age Differences in Human Spatial Navigation. Cerebral Cortex, 17, 1274-1282. (DOI: 10.1093/cercor/bhl036)

Raz, N., Rodrigue, K. M., & Haacke, E. M. (2007). Brain Aging and its Modifiers: Insights from in vivo neuromorphometry and Susceptibility Weighted Imaging. Annals of the New York Academy of Sciences, 1097, 84-93. (DOI: 10.1196/annals.1379.018)

Raz, N. & Rodrigue, K. M. (2006). Differential Aging of the Brain: patterns cognitive correlates, modifiers. Neuroscience and Biobehavioral Reviews, 30(6), 730-748.

(DOI: 10.1016/j.neubiorev.2006.07.001)

Rodrigue, K. M., Kennedy, K. M., & Raz, N. (2005). Aging and longitudinal change in perceptual-motor skill acquisition in healthy adults. Journal of Gerontology: Psychological Science, 60(4), P174-P181. (DOI: 10.1093/geronb/60.4.P174)

Raz, N., Lindenberger, U., Rodrigue, K. M., Kennedy, K. M., Head, D., Williamson, A., Dahle, C., Gerstorf, D. & Acker, J.D. (2005). Regional Brain Changes in Aging Healthy Adults: General Trends, Individual Differences, and Modifiers. Cerebral Cortex, 15(11), 1676-1689. (DOI: 10.1093/cercor/bhi044)

Raz, N. Rodrigue K. M., Kennedy, K. M., Acker, J. D. (2004). Hormone replacement therapy and age-related brain shrinkage: Regional effects, Neuroreport, 15 (16), 2531-2534. (DOI: 10.1097/00001756-200411150-00020)

Rodrigue, K. M. & Raz, N. (2004). Shrinkage of the entorhinal cortex over five years predicts memory performance in healthy adults, Journal of Neuroscience, 24(4), 956-963. (DOI: 10.1523/JNEUROSCI.4166-03.2004)

Raz, N., Rodrigue, K. M., Head, D., Kennedy, K. M., & Acker, J. D. (2004). Differential aging of the medial temporal lobe: A study of a five-year change. Neurology, 62 (3) 433-438. (DOI: 10.1212/01.WNL.0000106466.09835.46)

Raz, N., Gunning-Dixon, F., Head, D., Rodrigue, K. M., Williamson, A., & Acker, J. D. (2004). Aging, sexual dimorphism, and hemispheric asymmetry of the cerebral cortex: replicability of regional differences in volume. Neurobiology of Aging, (25), 377-396. (DOI: 10.1016/S0197-4580(03)00118-0)

Raz, N., Rodrigue, K. M., & Acker, J. D. (2003). Hypertension and the Brain: Vulnerability of the Prefrontal Regions and Executive Functions. Behavioral Neuroscience, 117(6), 1169-1180. (DOI: 10.1037/0735-7044.117.6.1169)

Raz, N., Rodrigue, K. M., Kennedy, K. M., Head, D., Gunning-Dixon, F., & Acker, J. D. (2003). Differential aging of the human striatum: Longitudinal evidence. American Journal of Neuroradiology, 24, 1849-1856. (PMID: 14561615)

Raz, N., Rodrigue, K. M., Kennedy, K. M., Dahle, C., Head, D., & Acker, J. D. (2003).  Differential Age-Related Changes in the Regional Metencephalic Volumes in Humans: A five year follow-up. Neuroscience Letters, 349(3), 163-166. (DOI: 10.1016/S0304-3940(03)00820-6)

Buskist, W., Tears, R. S., Davis, S. F., & Rodrigue, K. M. (2002). The teaching of psychology course: Prevalence and content. Teaching of Psychology, 29, 140-142.

Kennedy, K. M., Rodrigue, K. M., & Davis, S. F. (2000). So you want to teach less in hopes of teaching more? College Student Journal, 34(4), 626-632.

Davis, S. F., Smith, B. G., Rodrigue, K. M., & Pulvers, K. (1999).  An examination of internet usage on two college campuses. College Student Journal, 33, 257-260.