Karen M. Rodrigue, Ph. D.
Assistant Professor of Behavioral and Brain Sciences

Center for Vital Longevity
1600 Viceroy Drive,
Suite 800


Cognitive Neuroscience of Aging Lab

“Understanding the contributions of vascular health to normal and pathological aging is fundamentally important given both the prevalence of vascular risk in the aging population and its amenability to prevention and treatment.”

Research interests:

Keywords: cognitive aging, structural and functional changes with age, amyloid imaging, impact of health on brain aging, genetic influences on aging, individual differences

Dr. Rodrigue's research focuses on mapping the changes that the healthy human brain undergoes with aging and understanding how these changes affect behavior. She is specifically interested in how health factors such as hypertension in combination with genetic risk can shape the course of aging. Our lab uses a variety of tools to asses brain and cognitive aging including structural and functional MRI, beta-amyloid PET imaging and detailed cognitive and neuropsychological assessment.

Recent Publications

Rodrigue, K.M., Rieck, J.R., Kennedy, K.M., Devous, M.D., Diaz-Arrastia, R., & Park, D.C. (2012). Risk factors for β-amyloid deposition in healthy aging: vascular and genetic effects. JAMA Neurology, in press.

Rodrigue, K.M., Kennedy, K.M., Devous, M.D., Sr., Rieck, J.R., Hebrank, A.C., Diaz-Arrastia, R., Mathews, D., & Park, D.C. (2012). ß-amyloid burden in healthy aging: regional distribution and cognitive consequences. Neurology, 78, 387-395.

Kennedy, K. M., Rodrigue, K.M., Devous, M.D., Sr., Hebrank, A.C., Bischof, G. N.,  & Park, D.C. (2012). Effects of beta-amyloid accumulation on neural function during encoding across the adult lifespan. NeuroImage, 62, 1-8. doi: 10.1016/j.neuroimage.2012.03.077

Rodrigue, K.M., Daughtery, A., Haacke, E.M., & Raz, N. (2012).  The impact of hippocampal volume and iron deposition on memory in a lifespan sample of healthy aging. Cerebral Cortex, doi: 10.1093/cercor/bhs139

Liu, P., Hebrank, A.C., Rodrigue, K.M., Kennedy, K.M., Park. D.C., & Lu, H. (2012) A comparison of physiologic modulators of fMRI signals. Human Brain Mapping, doi: 10.1002/hbm.22053